Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis.

Authors

  • Nannan Niu
  • Ning Li
  • Xiaozhuan Liu
  • Xing Li
  • Xinjuan Pan
  • Xinjuan Yin
  • Zengli Yu
Abstract:

Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I2) were used to evaluate heterogeneity. In either cohort studies (I2=0.89, p

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Journal title

volume 8  issue 4

pages  351- 366

publication date 2015-02-01

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